Quetiapine Fumarate is an atypical antipsychotic medication that primarily exerts its effect through the antagonism of multiple neurotransmitter receptors, including serotonin 5-HT2A receptors and dopamine D2 receptors. Additionally, it has high affinity for histaminergic and adrenergic receptors.
1.Serotonin and Dopamine Receptors: Quetiapine's antagonism at serotonin 5-HT2A and dopamine D2 receptors is believed to contribute to its antipsychotic properties, improving symptoms such as hallucinations, delusions, and thought disorders.
2.Histaminergic Receptors: By blocking histamine H1 receptors, Quetiapine can have a sedative effect, which can be beneficial in treating insomnia or agitation associated with psychiatric conditions.
3.Adrenergic Receptors: Quetiapine's antagonism at adrenergic α1 receptors might result in orthostatic hypotension, while blocking α2 receptors can influence its antidepressant efficacy.
