Basic Chemical Information

• English Name: Entacapone

• CAS Number: 130929-57-6

• Molecular Formula: C14H15N3O5

• Molecular Weight: 305.289 g/mol

Pharmacological Effects

Entacapone is a catechol-O-methyltransferase (COMT) inhibitor used in the treatment of Parkinson's disease. Its primary pharmacological effects include:

  Mechanism of Action:
Entacapone works by inhibiting the enzyme catechol-O-methyltransferase (COMT). This enzyme is involved in the breakdown of catecholamines such as dopamine. By inhibiting COMT, entacapone increases the duration of action of levodopa, a precursor to dopamine, thereby enhancing its availability in the brain.