English Name: Lacosamide CAS Number: 175481-36-4 Molecular Formula: C13H18N2O3 Molecular Weight: 250.30 g/mol
Pharmacological Actions
Drug Type: Anticonvulsant (Anti-epileptic drug)
Mechanism of Action: 1. Sodium Channel Inhibition: Lacosamide selectively enhances slow inactivation of voltage-gated sodium channels without affecting the fast inactivation. This stabilization helps in reducing sustained repetitive firing of neurons and limits the neuronal hyperexcitability that can lead to seizures.
1.CRMP-2 Modulation: Lacosamide binds to collapsin response mediator protein-2 (CRMP-2), which is involved in neurodevelopment and has a role in neuronal differentiation and polarization. The exact role of this binding in its anticonvulsant effect is not fully understood but is thought to contribute to its therapeutic effects.
