Labetalol Hydrochloride is an essential pharmaceutical compound primarily used in the treatment of hypertension, particularly hypertensive disorders complicating pregnancy. Below is a detailed analysis of Labetalol Hydrochloride:
I. Basic Information
English Name: Labetalol Hydrochloride
Alternative Names: Trandate, Normodyne, 2-Hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]benzamide Hydrochloride
CAS Number: 32780-64-6
Molecular Formula: C19H25ClN2O3
Molecular Weight: 364.87 g/mol
EINECS Number: 251-211-1
II. Physical and Chemical Properties
Melting Point: Approximately 187-189°C
Solubility: Soluble in water
Storage Conditions: Recommended storage temperature of 2-8°C
III. Pharmacological Effects
Labetalol Hydrochloride possesses both alpha and beta receptor blocking actions with weak intrinsic activity and membrane-stabilizing properties.
Its beta receptor blocking effect is approximately 4-8 times that of its alpha receptor blocking effect, with a beta1 receptor blocking effect roughly one-fourth that of propranolol and a weaker beta2 receptor blocking effect.
By blocking beta receptors while simultaneously exerting a vasodilatory effect through blocking alpha receptors, it contributes to its antihypertensive and anti-anginal mechanisms.
Compared to pure beta blockers, Labetalol Hydrochloride exhibits stronger hypotensive effects during standing and exercise tests and increases renal blood flow.
IV. Indications
Indications: Suitable for the treatment of mild to severe hypertension and angina pectoris; intravenous administration can treat hypertensive crises, particularly in hypertensive pregnant women or those with preeclampsia, pheochromocytoma, malignant hypertension, and hypertensive crises.
