Cefotaxime Sodium is an organic compound with the systematic name of sodium (6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)acetamido]-3-acetoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate. It belongs to the third-generation semisynthetic cephalosporins.
Basic Information
English Name: Cefotaxime Sodium
CAS Number: 64485-93-4
Molecular Formula: C16H16N5NaO7S2
Molecular Weight: 477.447
Pharmacological Action
Cefotaxime Sodium is less active against Gram-positive bacteria compared to cefazolin. It is resistant to enterococci and ineffective against penicillin-resistant pneumococci. However, it exhibits potent bactericidal activity against Gram-negative bacteria, particularly Escherichia coli, influenza bacilli, Klebsiella pneumoniae, Proteus mirabilis, and Salmonella species. However, it is not sensitive to Pseudomonas aeruginosa and Enterobacter cloacae, and has weak or resistant activity against Bacteroides fragilis.
Clinical Applications
Cefotaxime Sodium is primarily used for a wide range of infections caused by susceptible organisms, including:
Respiratory, urinary, bone and joint, skin and soft tissue, abdominal, biliary, digestive, ENT, and genital infections
Burns, trauma-induced infections
Septicemia, central nervous system infections, etc.
