Hydroxychloroquine Sulfate is a widely used medication primarily employed in the treatment of various rheumatological and immunological diseases.
Basic Information
Chemical Name: 2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl]ethylamino]ethanol sulfate
CAS No.: 747-36-4
Chemical Formula: C18H28ClN3O5S
Molecular Weight: 433.95
Indications
Hydroxychloroquine Sulfate is primarily used to treat various rheumatological and immunological diseases, including:
Rheumatoid arthritis
Chronic arthritis in adolescents
Discoid and systemic lupus erythematosus
Skin diseases triggered or exacerbated by sunlight
Pharmacological Action
Hydroxychloroquine Sulfate is a synthetic antimalarial drug whose primary uses have expanded to the treatment of rheumatological and immunological diseases. Its pharmacological actions include:
Inhibition of Toll-like receptor 7/9 (TLR7/9) signaling
Interference with enzyme activities (e.g., phospholipases, NADH-cytochrome C reductase)
Stabilization of lysosomal membranes
Inhibition of prostaglandin formation
Inhibition of polymorphonuclear cell chemotaxis and phagocytic cell function
These effects collectively contribute to the drug's efficacy in treating rheumatological and immunological diseases.
