Chemical Name: 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil Hydrochloride
English Name: Urapidil Hydrochloride
CAS Number: 64887-14-5
EINECS Number: 636-348-0 (provided by some sources)
Molecular Formula: C20H30ClN5O3
Molecular Weight: 423.94 (some sources give 423.9369, reflecting slight differences in decimal precision)
Physical Properties
Melting Point: 156-158ºC
Boiling Point: 549ºC at 760 mmHg
Flash Point: 285.8ºC
Water Solubility: Soluble
Pharmacological Effects
Mechanism of Action: Urapidil Hydrochloride is an α1-adrenoceptor antagonist and 5-HT1A receptor agonist. It exerts its hypotensive effects by dilating peripheral blood vessels and reducing peripheral resistance through blocking α1 receptors, while also stimulating 5-HT1A receptors to decrease sympathetic feedback regulation in the medullary cardiovascular center.
Clinical Applications
Indications: Primarily used in the treatment of hypertensive crises (such as acute elevations of blood pressure), severe and very severe hypertension, as well as resistant hypertension.
Dosage and Administration: Administered via intravenous injection or continuous intravenous infusion, with the specific dosage adjusted according to the patient's condition.
Storage and Transportation
Storage Conditions: Store in a light-protected, dry, and sealed container. The validity period typically ranges from 24 months to 3 years, depending on the manufacturer's specifications.
Transportation Conditions: Maintain room temperature during transportation and avoid extreme temperatures and high humidity environments.
