Alendronate Sodium is an orally active nitrogen-containing bisphosphonate primarily used in the treatment of bone metabolism-related diseases.
Basic Information
English Name: Alendronate Sodium Trihydrate
CAS Number: 121268-17-5
Molecular Formula: C4H12NNaO7P2·3H2O
Molecular Weight: 325.12
Pharmacological Actions
As a third-generation bisphosphonate, Alendronate Sodium primarily targets osteoclasts, where it accumulates. It is ingested ten times more by osteoclasts compared to osteoblasts. By binding to hydroxyapatite in bone, it inhibits osteoclast activity and their ability to release H+, reducing the production of osteoclast-activating factors and thereby decreasing the number of active osteoclasts. This suppression of osteoclast activity leads to reduced bone turnover, fewer bone remodeling sites, and a net increase in bone formation over bone resorption, ultimately preventing bone loss and increasing bone density.
Indications
Treatment and prevention of postmenopausal osteoporosis to reduce the risk of hip and spinal fractures.
Hypercalcemia associated with malignancy.
Bone pain caused by osteolytic cancer metastases.
Other conditions associated with increased bone resorption, such as Paget's disease.
