Daptomycin exerts its antibacterial effects by interfering with the function of bacterial cell membranes. Its primary mechanisms include:
Membrane Depolarization: Daptomycin binds to phospholipids in bacterial cell membranes, particularly under the promotion of calcium ions. This binding causes the bacterial cell membrane to lose its electrochemical gradient (depolarization), thereby halting the synthesis of ATP and leading to bacterial death.
Membrane Integrity Damage: By forming pores in the cell membrane, Daptomycin compromises the integrity of the membrane, preventing it from properly maintaining appropriate ion gradients and other vital molecular gradients.
