Iguratimod is a medication used for the treatment of active rheumatoid arthritis (RA).
Basic Information
English Name: Iguratimod
CAS Number: 123663-49-0
Molecular Formula: C17H14N2O6S
Molecular Weight: 374.37
Pharmacological Action
Iguratimod functions as an anti-rheumatic agent primarily through the following mechanisms:
Inhibition of COX-2 Activity: Iguratimod effectively inhibits COX-2 activity with an IC50 value of 20 μM (7.7 μg/mL), while showing no effect on COX-1. This allows it to reduce inflammation and pain without the common gastrointestinal side effects associated with non-steroidal anti-inflammatory drugs (NSAIDs).
Inhibition of MIF (Macrophage Migration Inhibitory Factor): Iguratimod is also an inhibitor of MIF with an IC50 value of 6.81 μM. By inhibiting MIF, it further mitigates inflammatory responses.
Indications and Dosage
Indications: Primarily indicated for the treatment of active rheumatoid arthritis, providing anti-inflammatory, analgesic, and disease-modifying effects.
