Diclofenac Sodium, a non-steroidal anti-inflammatory drug (NSAID), possesses potent analgesic, anti-inflammatory, and antipyretic properties. It is widely used in the treatment of various painful and inflammatory conditions.
Basic Information
Generic Name: Diclofenac Sodium
Chemical Formula: C14H10Cl2NNaO2
Molecular Weight: 318.13
CAS Registry Number: 15307-79-6
Pharmacological Action
Diclofenac Sodium exerts its therapeutic effects by inhibiting cyclooxygenase activity, thereby blocking the conversion of arachidonic acid to prostaglandins. This inhibition results in analgesia, anti-inflammation, and antipyresis. Among NSAIDs, Diclofenac Sodium is considered one of the more potent agents in suppressing prostaglandin synthesis, surpassing aspirin and indomethacin.
Indications
Diclofenac Sodium is indicated for the treatment of numerous painful and inflammatory conditions, including but not limited to:
Acute and chronic rheumatic or rheumatoid arthritis
Acute and chronic arthritis
Acute and chronic ankylosing spondylitis
Shoulder periarthritis, bursitis, myositis, and tenosynovitis
Low back pain, sprains, strains, and other soft tissue injuries
Acute gout
Dysmenorrhea, dental pain, and postoperative pain
Severe infectious pain and inflammation in the ear, nose, and throat (e.g., tonsillitis, otitis, sinusitis), in conjunction with antimicrobials
