Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) that has achieved significant milestones in both biological research and clinical applications since its introduction.
I. Basic Information
English Name: Meloxicam
Chemical Formula: C14H13N3O4S2
Molecular Weight: 351.4
CAS Number: 71125-38-7
II. Pharmacological Action
Meloxicam exerts its anti-inflammatory, analgesic, and antipyretic effects by inhibiting the activity of cyclooxygenase (COX) enzymes, particularly COX-2, in the body, thereby blocking the synthesis of prostaglandins. Compared to traditional NSAIDs, Meloxicam demonstrates stronger inhibition of COX-2 while exerting weaker inhibition of COX-1, which partly contributes to reducing gastrointestinal side effects.
III. Clinical Applications
Pain Management: Meloxicam is widely used in managing pain associated with osteoarthritis, rheumatoid arthritis, and other conditions. Its significant analgesic effect and long duration of action contribute to improving patients' quality of life.
Anti-inflammatory Effect: By inhibiting the production of inflammatory mediators, Meloxicam can alleviate inflammatory responses, effectively relieving pain, swelling, and other symptoms caused by inflammation.
Antipyretic Effect: Meloxicam also possesses a mild antipyretic effect, making it useful in treating fever symptoms resulting from inflammation.
