Basic Information

• Chinese Name: 托伐普坦

• English Name: Tolvaptan

• CAS Number: 150683-30-0

• Molecular Formula: C26H25ClN2O3

• Molecular Weight: 448.947

• EINECS Number: 1308068-626-2

Physical and Chemical Properties

• Density: 1.311

• Melting Point: 219-222°C

• Boiling Point: 594.4 °C at 760 mmHg

• Refractive Index: 1.663

• Flash Point: 313.3 °C

• Vapor Pressure: 0.0±1.8 mmHg at 25°C

• PSA: 69.64000

• LogP: 5.82110

• Solubility: Has low solubility in water, approximately 0.1088 mg/L at 25°C (estimated)

Stability and Storage

• Stability: Stable under recommended storage conditions

• Storage Temperature: 2-8°C

Uses and Pharmacological Effects

• Uses: Tolvaptan is primarily used in the pharmaceutical industry, specifically as an oral tablet formulation.

• Pharmacological Effects: Tolvaptan is a V2 receptor antagonist of arginine vasopressin (antidiuretic hormone) used in the treatment of low sodium levels in the blood (hyponatremia). It works by increasing water excretion by the kidneys, thereby helping to restore normal serum sodium concentrations.