Voglibose

Voglibose is an α-glucosidase inhibitor primarily used to improve postprandial hyperglycemia in diabetic patients. 

I. Basic Information

• Chemical Name: (+)-1L-[1(hydroxy),2,4,5/3]-5-[2-hydroxy-1-(hydroxymethyl)ethyl]amino-1-C-(hydroxymethyl)-1,2,3,4-cyclohexanetetrol

• English Name: Voglibose

• CAS Number: 83480-29-9

• Molecular Formula: C10H21NO7

• Molecular Weight: 267.28

II. Pharmacological Action

As an α-glucosidase inhibitor, Voglibose competitively inhibits intestinal disaccharidase (α-glucosidase) enzymes, thus delaying the digestion and absorption of carbohydrates and improving postprandial hyperglycemia. This is crucial in preventing the progression of diabetes and its complications.

III. Clinical Applications

• Indications: Used when diet therapy and exercise therapy alone are not effective, or when these methods combined with oral hypoglycemic agents or insulin therapy do not provide significant improvement.