☏
@
Home ∷ Medications for the circulatory system ∷ Lercanidipine Hydrochloride
placement：
Product
Article
Search
NameDescriptionContent
Product Showcase
Lercanidipine Hydrochloride
    Publish time 2024-09-19 15:42    

CAS NO.: 132866-11-6

Lercanidipine Hydrochloride

Lercanidipine Hydrochloride, also known as Lercanidipine HCl, is an important pharmaceutical intermediate and active pharmaceutical ingredient. Here is a detailed translation of the information about Lercanidipine Hydrochloride:

I. Basic Information

  • English Name: Lercanidipine Hydrochloride

  • Chinese Name: 盐酸乐卡地平

  • CAS Number: 132866-11-6

  • Molecular Formula: C36H42ClN3O6 (Note: Molecular weight values may vary slightly between sources but generally fall within the range)

  • Molecular Weight: 648.19 (Approximate, as values may vary slightly)

  • Appearance: Off-white to yellow powder (Color may vary depending on purity and state)

II. Chemical Properties

  • Melting Point: Ranges from 116-122°C to 175-177°C, depending on sources.

  • Boiling Point: 712.5°C at 760 mmHg

  • Flash Point: 384.7°C

  • Vapor Pressure: 3.77E-20 mmHg at 25°C

  • Solubility: Slightly soluble in DMSO and Methanol

III. Biological Activity and Pharmacological Effects

Lercanidipine Hydrochloride is a third-generation, lipophilic, blood-brain barrier permeable, and vasoselective dihydropyridine calcium channel blocker. Its pharmacological effects include:

  • Prolonged antihypertensive action: Effectively lowers blood pressure.

  • Renal and neuroprotective effects: Provides protection to the kidneys and nervous system.

  • Antioxidant, anti-inflammatory, and anti-apoptotic properties: Demonstrates various biological activities.

IV. Uses

  • Pharmaceutical Use: Primarily used in cardiovascular and neurological research, and for clinical treatment of hypertension and related conditions (specific dosing and administration should follow medical advice).

  • Scientific Research: Serves as a tool drug in scientific research to explore mechanisms of calcium channel blockade and related disease models.

V. Safety Information

  • Risk Phrases (R-phrases): R25 (Toxic if swallowed)

  • Safety Phrases (S-phrases): S45 (In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)); S36/37 (Wear suitable protective clothing and gloves)

VI. Storage Conditions

  • Generally stored at -20°C to maintain stability and activity. Specific storage conditions may vary depending on product specifications and intended use.