Diquafosol Sodium, known as Dequafosol Sodium in some contexts, is a crucial ophthalmic drug ingredient primarily used to treat dry eye disease associated with corneal and conjunctival epithelial damage caused by abnormal tear secretion.
I. Basic Information
English Name: Diquafosol Sodium
CAS Number: 211427-08-6
Molecular Formula: C18H22N4Na4O23P4
Molecular Weight: 878.23
II. Physical Properties
Appearance: White crystalline powder, odorless, with hygroscopicity
Solubility: Highly soluble in water, but insoluble or nearly insoluble in some organic solvents
III. Pharmacological Action
Diquafosol Sodium, a dinucleotide derivative, works by activating the P2Y2 receptors on conjunctival tissues and goblet cell membranes. This leads to an increase in intracellular calcium ion concentration, promoting the secretion of tear fluid containing water and mucin. Consequently, it improves the quality and quantity of the tear film, allowing it to approach normal conditions, thereby alleviating dry eye symptoms and repairing corneal and conjunctival epithelial damage.
IV. Clinical Application
Indications: Suitable for patients diagnosed with dry eye disease associated with corneal and conjunctival epithelial damage caused by abnormal tear secretion.
