Aminophylline is an important drug for the treatment of respiratory diseases.
Basic Information:
English Name: Aminophylline
CAS Number: 317-34-0
Chemical Structure: C16H24N10O4
Molecular Weight: 420.43
Pharmacological Action:
Aminophylline primarily exerts its effects through its theophylline component, with the addition of ethylenediamine enhancing its water solubility. Its main actions include:
Relaxation of Bronchial Smooth Muscles: It relaxes bronchial smooth muscles, alleviating bronchospasm or constriction, thereby improving ventilation function.
Cardiac and Renal Effects: It dilates renal afferent and efferent arterioles, increasing glomerular filtration rate and renal blood flow, inhibiting sodium and chloride reabsorption in the distal renal tubules.
Other Effects: It also relaxes various smooth muscles, including those in the intestines and bile ducts, and alleviates congestion and edema in bronchial mucosa. Additionally, it enhances skeletal muscle contractility, particularly in cases of chronic obstructive pulmonary disease.
Indications:
Aminophylline is primarily used in the treatment of respiratory diseases such as:
Bronchial asthma
Asthmatic bronchitis
Chronic obstructive pulmonary disease
Cardiogenic and renal edema
It can also be used in the treatment of cardiac asthma (asthma caused by cardiogenic pulmonary edema).
