Isoprenaline Hydrochloride

Isoprenaline Hydrochloride is a non-selective β-adrenoceptor agonist with notable physiological effects and broad application value. 

I. Basic Information

• Chemical Name: 4-(1R)-1-Hydroxy-2-[(1-methylethyl)aminoethyl]benzene-1,2-diol hydrochloride

• English Name: Isoprenaline Hydrochloride; Isoproterenol; Non-selective beta adrenoceptor agonist; Isoprenaline HCl

• CAS Number: 51-30-9

• Molecular Formula: C11H17NO3·HCl

• Molecular Weight: 247.72

II. Pharmacological Effects

Isoprenaline Hydrochloride exerts its various physiological effects mainly by stimulating α1, α2, β1, and β2 receptors:

• Stimulation of α1 and α2 Receptors: Causes vasoconstriction in the skin and mucous membranes, inhibits histamine-induced bronchial spasms, treats nasal mucosal edema, and reduces rhinorrhea.

• Stimulation of β1 Receptors: Primarily dilates blood vessels, enhances cardiac contractility, accelerates heart rate, and increases cardiac output. This effect is particularly important in rescuing patients with cardiac arrest, restoring blood circulation, and normalizing slowed heart rates.

• Stimulation of β2 Receptors: Has a significant therapeutic effect on various types of asthma, directly relaxing bronchial smooth muscles and alleviating bronchial spasms.

Additionally, Isoprenaline Hydrochloride can stimulate the central nervous system and counteract the paralyzing effects of central stimulants.

III. Clinical Applications

• Treatment of Cardiac Arrest

• Treatment of Third-Degree Atrioventricular Block