Basic Information

• Product Name: Bumetanide

• Molecular Formula: C17H20N2O5S

• CAS Number: 28395-03-1

• EINECS Number: 249-004-6

Physical Properties

• Appearance: White crystalline powder, some sources describe it as a white to light yellow to light orange solid

• Melting Point: 230-231°C

• Boiling Point: 571.2±60.0°C (predicted value)

• Density: Approximately 1.2812 (rough estimate) or 1.3±0.1 g/cm³

• Refractive Index: 1.6510 (estimated value) or 1.612

• Solubility: Soluble in water, alcohol, and alkaline solutions; insoluble or sparingly soluble in acidic solutions. Specifically, it is soluble in ethanol, slightly soluble in chloroform (or dichloromethane), and insoluble or sparingly soluble in water. Some sources also indicate that it has certain solubility in organic solvents such as acetone, benzene, methanol, and propylene glycol.

Chemical Properties

• Stability: Stable under normal temperature and pressure

• Acid Dissociation Constant (pKa): pK1 3.6, pK2 7.7 (at 25°C)

Uses and Toxicity

• Uses: Bumetanide is a mercury-free, non-benzothiazine, high-efficiency, low-toxicity new diuretic with a diuretic effect 40 times higher than furosemide. It is mainly used for the treatment of various edema and lowering blood pressure. Additionally, it is an Na+-K+-2Cl- cotransporter inhibitor with inhibitory effects on both NKCC1 and NKCC2.

• Toxicity: The LD50 for intravenous injection in mice is 330 mg/kg. It is irritating to the skin, eyes, and respiratory tract and may cause damage. Therefore, appropriate protective measures should be taken when handling and storing bumetanide.