Molecular Weight: 529.52 g/mol (or 529.51600 g/mol with higher precision)
Physical Properties
Appearance: Nilotinib is a grayish-white solid.
Density: 1.36 g/cm³
Refractive Index: 1.65
Melting Point: Not specifically mentioned, but it is a solid at room temperature.
Solubility: Solubility information is not provided, but it is likely to be soluble in certain organic solvents.
Chemical Properties
Structure: Nilotinib has a specific chemical structure with a molecular formula of C28H22F3N7O.
Mechanism of Action: Nilotinib is a high-affinity ATP-competitive inhibitor based on aminopyrimidine. It selectively inhibits Bcr-Abl autophosphorylation and reduces the proliferation and developmental ability of wild-type Bcr-Abl and imatinib-resistant mutant cells.
Biological Activity
Antitumor Activity: Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity. It is effective in the treatment of chronic myeloid leukemia (CML) patients who are resistant or intolerant to imatinib.
Pharmacodynamics: After oral administration, nilotinib is absorbed into the bloodstream and distributed to tissues. It inhibits the activity of Bcr-Abl tyrosine kinase, thereby inhibiting the proliferation of leukemic cells and inducing their apoptosis.
Applications
Therapeutic Use: Nilotinib is used for the treatment of patients with CML who are resistant or intolerant to imatinib.
Research Use: It is also used in scientific research to study its mechanisms of action, antitumor activity, and interactions with other drugs or biological systems.
