Basic Information

• Product Name: Neratinib Maleate

• Synonyms: HKI-272 Maleate, Neratinib Maleate Salt, Maleate of Neratinib

• CAS Number: 915942-22-2

• Molecular Formula: C30H29ClN6O3•C4H4O4

• Molecular Weight: 673.11

• Form: Solid

• Color: White to off-white

Pharmacological Properties

• Drug Type: An orally effective, irreversible pan-human epidermal growth factor receptor (EGFR) inhibitor

• Inhibited Receptors: Inhibits HER1, HER2, and HER4 receptors and their associated tyrosine kinases

• Mechanism of Action: Blocks the transduction of HER1, HER2, and HER4 signaling pathways to achieve anticancer effects

Indications

• Used as adjuvant therapy in adult patients with early-stage HER2-overexpressed or amplified breast cancer

• Also used to treat digestive system diseases, respiratory system diseases, urogenital system diseases, skin and musculoskeletal diseases

• Can be used for research in breast cancer and prostate cancer