Physical and Chemical Properties: It is a slightly yellow crystal or powder with a melting point of 205°C (some reports indicate decomposition at 250~255°C). It is easily soluble in acids, slightly soluble in methanol and ethanol, and insoluble in water. It decomposes with heat and is unstable to acids and light.
Drug Characteristics
Mechanism of Action: Dacarbazine is a precursor of purine biosynthesis that can interfere with purine biosynthesis. It interacts with DNA in vivo to inhibit the growth and division of tumor cells. Specifically, dacarbazine binds to the bases in cancer cell DNA, interfering with cancer cell DNA replication and thereby preventing cancer cell proliferation.
Indications: It is primarily used for the treatment of malignant tumors such as melanoma, soft tissue tumors, and malignant lymphomas (such as Hodgkin's disease). Additionally, it has a certain efficacy in lung squamous cell carcinoma, sarcomas, leiomyosarcomas, and fibrosarcomas, but is not effective for gastrointestinal cancers.
