I. Basic Information

• Product Name: Palbociclib

• CAS Number: 571190-30-2

• Molecular Weight: 447.53

• Molecular Formula: C24H29N7O2

• Appearance: Yellow to off-white crystalline solid

II. Physical Properties

• Density: 1.3±0.1 g/cm3 (or 1.313±0.06 g/cm3, predicted value)

• Boiling Point: 711.5±70.0 °C at 760 mmHg

• Melting Point: 200ºC

• Flash Point: 384.1±35.7 °C

• Solubility: Soluble in DMSO (up to 2 mg/ml under heating conditions)

• pKa: 8.66±0.10 (predicted value)

III. Biological Activity and Pharmacological Effects

Palbociclib is an orally available pyrido[2,3-d]pyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antitumor activity. It is a highly specific inhibitor of CDK4 and CDK6, with IC50 values of 0.011 μmol/L and 0.016 μmol/L, respectively, and inactive against other 36 protein kinases. By inhibiting the activity of CDK4/6 enzymes, Palbociclib can target tumor cells and restore cell cycle control, thereby blocking tumor cell proliferation.