Appearance: White or light brown crystalline powder
Melting Point: 114~119°C
Boiling Point: Various reports, such as 464.0±28.0°C at 760 mmHg (another estimate is 359.3°C)
Density: 1.4±0.1 g/cm3 (another estimate is 1.305)
Refractive Index: 1.471 (another estimate is 1.5630)
Flash Point: 234.4±24.0°C (another report is 9°C)
Solubility: Very slightly soluble in water, soluble in acetone and acetonitrile, very slightly soluble in ethanol (96%)
Chemical Properties & Uses
Category: Alkylating agent, antineoplastic agent
Mechanism of Action: Acts by alkylating guanine within cellular DNA, disrupting the structure and function of DNA, thereby inhibiting cell growth and proliferation. It has immunosuppressive and myeloablative chemotherapy activity.
Primary Uses: Primarily used in the treatment of chronic myelogenous leukemia with a remission rate of 80~90%. It is also used to establish animal models of acute aplastic anemia.
Toxicity: Toxic; long-term use can lead to myelosuppression and even aplastic anemia. It is classified as a Group 1 carcinogen by the International Agency for Research on Cancer (IARC).
