Storage Conditions: Typically stored at -20°C under lyophilized and light-protected conditions, with a recommended shelf life of 2 years at -80°C or 1 year at -20°C; in solvent, store at -80°C for up to 6 months or -20°C for up to 1 month. Ensure the product is sealed and dry.
Solubility: Soluble in appropriate solvents for scientific research or pharmacological experiments.
Biological Properties and Pharmacological Effects
Target: Degarelix Acetate is a competitive and reversible antagonist of the human gonadotropin-releasing hormone (GnRH) receptor.
Mechanism of Action: By inhibiting the release of GnRH from the pituitary gland, it reduces the levels of testosterone (a hormone that promotes the growth of prostate cancer), thereby slowing or stopping the growth of prostate cancer cells.
Biological Activity: Degarelix Acetate has high affinity/selectivity for the human GnRH receptor with an IC50 value of 3 nM.
In Vivo and In Vitro Studies: In vivo studies have shown that Degarelix Acetate reduces plasma luteinizing hormone (LH) levels and plasma testosterone levels in a dose-dependent manner in orchidectomized rats. In vitro studies have demonstrated that Degarelix Acetate decreases cell viability in multiple prostate cell lines and directly affects prostate cell growth by inducing apoptosis.
Main Applications
Scientific Research: Degarelix Acetate is widely used in prostate cancer research and pharmacological experiments related to GnRH receptor studies.
Pharmacological Experiments: As a GnRH receptor antagonist, Degarelix Acetate can be used to identify and evaluate the growth inhibitory effects of drugs on prostate cancer cells.
