Appearance: Light pink, light gray, or light orange capsules (color may vary by specification), with imprinted identification and specifications on the capsule shell. The contents are white powder.
Storage Conditions: The powder should be stored at -25-15°C with a shelf life of 3 years. If dissolved in a solvent, it should be stored at -85-65°C with a shelf life of 2 years.
Pharmacological Action
Mechanism of Action: Ixazomib Citrate is a reversible inhibitor that acts on the chymotrypsin-like protein at the β5 site in the 20S proteasome for hydrolysis. Its IC50 value is 3.4 nM, and its Ki value is 0.93 nM.
Indications: It is primarily used to treat adult patients with multiple myeloma who have received at least one prior therapy. When combined with lenalidomide and dexamethasone, it enhances treatment efficacy.
