Basic Information

• Product Name: Sorafenib Tosylate

• CAS Number: 475207-59-1

• Molecular Formula: C21H16CLF3N4O3·C7H8SO3

• Molecular Weight: 637.03

• Aliases: 4-{4-[3-(4-Chloro-3-trifluoromethylphenyl)ureido]phenoxy}pyridine-2-carboxamide tosylate; Sorafenib tosylate; Tosylate Sorafenib; Sorafenib intermediate

• Purity: Available in multiple purity grades, such as 99.91%, 99.73%, etc.

• Appearance: White to off-white crystalline powder

Physical Properties

• Density: 1.454 g/cm³

• Boiling Point: 523.3°C at 760 mmHg

• Flash Point: 270.3°C

Chemical Properties

• Multi-kinase Inhibitory Activity: Sorafenib Tosylate is a multi-kinase inhibitor that can inhibit the activity of various kinases, including Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, etc., with IC50 values of 6 nM, 22 nM, 90 nM, 15 nM, 20 nM, 20 nM, 57 nM, and 58 nM, respectively.

• Antitumor Activity: It exhibits significant antitumor activity by inducing autophagy and apoptosis, and can also stimulate ferroptosis.