Rebamipide, also known as Recamide, is a medication primarily used in the treatment of gastritis and gastric ulcers. Below is a detailed introduction to Rebamipide:

Basic Information

• English Name: Rebamipide

• CAS Number: 90098-04-7 (Note: Some sources may list 111911-87-6, but 90098-04-7 is the more widely accepted CAS number)

• Molecular Formula: C19H15ClN2O4

• Molecular Weight: 370.7864 (Some sources may list 370.79)

Indications

Rebamipide is used to treat the following conditions:

1. Gastric Ulcers: It promotes ulcer healing.

2. Acute Gastritis and Acute Exacerbation of Chronic Gastritis: It improves gastric mucosal lesions such as erosions, bleeding, hyperemia, and edema.

Pharmacological Effects

Rebamipide acts as a gastric mucosal protective agent with the following pharmacological effects:

1. Increases Gastric Mucosal Blood Flow: Enhances mucosal repair and regeneration by increasing blood supply to the gastric mucosa.

2. Promotes Synthesis of Prostaglandin E2 (PGE2): PGE2 has a protective effect on the gastric mucosa, reducing its damage.

3. Scavenges Oxygen Free Radicals: Removes oxygen free radicals from the body, mitigating their damage to the gastric mucosa.

4. Inhibits Neutrophil Activation: Reduces the production of reactive oxygen species by activated neutrophils, further protecting the gastric mucosa.

Adverse Reactions

Rebamipide has relatively few adverse reactions, but some patients may experience the following:

1. Hematological System: Leukopenia, thrombocytopenia, etc., but these occur infrequently.

2. Nervous System: Numbness, dizziness, drowsiness, etc.

3. Gastrointestinal: Taste disturbances, belching, hiccups, vomiting, gastric burning sensation, abdominal pain, bloating, constipation, diarrhea, etc.

4. Liver: Abnormal liver function, such as elevated alanine aminotransferase (ALT), aspartate aminotransferase (AST), and jaundice.

5. Endocrine/Metabolism: Breast swelling, breast pain, gynecomastia in males, induction of lactation, etc.

6. Respiratory System: Cough, dyspnea, etc.

7. Allergic Reactions: Skin rashes, itching, drug eruption-like eczema, and occasionally urticaria.