English Name: Nintedanib (also known as BIBF-1120 or VARGATEF)
CAS Number: 928326-83-4
Molecular Formula: C31H33N5O4
Molecular Weight: 539.625 (or 539.633, slight variations may occur from different sources)
Physical and Chemical Properties
Density: 1.284 g/cm³ (or 1.3±0.1 g/cm³, depending on measurement conditions)
Boiling Point: 742.199°C at 760 mmHg (or 742.2±60.0°C at 760 mmHg)
Flash Point: 402.667°C (or 402.7±32.9°C)
Melting Point: 305°C (as reported by some sources)
Refractive Index: 1.658
Vapor Pressure: 0.0±2.5 mmHg at 25°C
PSA: 94.22000
LogP: 3.70270 (or 2.59, depending on the calculation method)
Uses and Characteristics
Nintedanib is a multi-target tyrosine kinase inhibitor used primarily in anti-cancer therapy. It inhibits vascular endothelial growth factor receptors (VEGFR), fibroblast growth factor receptors (FGFR), and platelet-derived growth factor receptors (PDGFR), thereby blocking angiogenesis and proliferation of tumor cells.
This drug is used to treat idiopathic pulmonary fibrosis (IPF) and certain types of lung cancer, such as non-small cell lung cancer (NSCLC).
