Chemical Names (Other): Trilafon, Ethylperazine, Decentan, etc.
CAS Number: 58-39-9
Molecular Formula: C21H26ClN3OS
Molecular Weight: 403.97 g/mol
Pharmacological Actions
Perphenazine is an antipsychotic belonging to the class of medications known as phenothiazines. It exhibits several pharmacological effects as follows:
1.Antipsychotic Effect: Perphenazine primarily functions by antagonizing dopamine D2 receptors in the brain, which helps to alleviate symptoms of schizophrenia and other psychotic disorders.
2.Antiemetic Action: It also acts on the chemoreceptor trigger zone (CTZ) in the brain, giving it antiemetic properties that help prevent nausea and vomiting.
3.Sedative Effect: Due to its blocking action on histamine H1 receptors, perphenazine produces a sedative effect, which can be beneficial in agitated patients.
4.Anticholinergic Effect: Perphenazine has some degree of anticholinergic activity, contributing to its side effect profile, such as dry mouth, constipation, and blurred vision.
5.Alpha-Adrenergic Blocking Effect: It can induce hypotension due to its alpha-adrenergic blocking properties, especially when initiating therapy or increasing dose rapidly.
