Basic Information

• English Name: Amiodarone Hydrochloride

• Chinese Name: 盐酸胺碘酮

• CAS Number: 19774-82-4

• EINECS Number: 243-293-2

• Molecular Formula: Typically C25H29I2NO3·HCl (note: variations in molecular formulas may exist due to isotopic labeling or salt forms)

• Molecular Weight: 681.7726 (without isotopic labeling)

Physical and Chemical Properties

• Melting Point: 154-158°C

• Solubility: Very slightly soluble in water, freely soluble in dichloromethane, soluble in methanol, slightly soluble in ethanol

• pKa: pKa (25°C) 6.56 ±0.06

• Stability: Stable in DMSO or ethanol solutions at -20°C for up to 2 months

Applications

Hydrochloride Amiodarone is a potent antiarrhythmic agent that inhibits both fast sodium channels and slow calcium channels. It also affects thyroid hormone metabolism, exhibits non-competitive antisympathetic effects, regulates thyroid function, and modulates phospholipid metabolism. Additionally, Amiodarone HCl is a sodium/potassium-ATPase inhibitor and an activator of autophagy, making it useful in treating various cardiac arrhythmias.

Safety Data

• Hazard Symbols: GHS07, GHS08, GHS09

• Signal Words: Warning

• Hazard Statements: Including H312+H332, H315, H319, H361d, H373, H410, etc.

• Precautionary Statements: Including P260, P280, P305+P351+P338, etc.

• Risk Phrases: Xn, T, F

• R-Phrases: Including R20/21/22, R39/23/24/25, R23/24/25, R11, etc.

• S-Phrases: Including S36, S45, S36/37, S16, S7, etc.

• UN Number for Transport: UN1230 - Class 3 - PG 2 - Methanol, solution