Alternative Names: Ardeparin Sodium, Sodium Heparin Salt, Heparin Sodium Salt
CAS Number: 679809-58-6
Molecular Weight: Approximately 1859.43 (note that different sources may provide slightly different values)
Chemical Formula: C57H82N4Na4O53S3
Physical and Chemical Properties
Melting Point: >191°C (decomposes)
Solubility: Slightly soluble in water, resulting in a clear, slightly yellow liquid
Storage Conditions: 2-8°C, or at room temperature under an inert atmosphere
Pharmacological Effects
Enoxaparin Sodium exerts its anticoagulant effect primarily by enhancing the activity of antithrombin III (AT-III), inhibiting coagulation factors Xa and IIa (i.e., thrombinase and thrombin). Its ratio of anti-Xa to anti-IIa activity is greater than 4, making it effective in preventing thrombosis.
Indications
Prevention: Used to prevent venous thrombosis following orthopedic and general surgical procedures, as well as coagulation during extracorporeal circulation during hemodialysis.
Treatment: Prevention of deep venous thrombosis (DVT) and pulmonary embolism, and treatment of established DVT.
Drug Interactions
Enoxaparin Sodium may interact with certain medications, such as anticoagulants and thrombolytics. Avoid concurrent use with these drugs or adjust dosages as necessary.
In summary, Enoxaparin Sodium is a crucial anticoagulant drug with a wide range of indications and significant pharmacological effects.
