Basic Chemical Information:

• English Name: Blonanserin

• Chemical Name: (R)-(1-(4-fluorophenyl)-2-(1-methyl-1,3-dihydro-2H-benzo[e]indol-2-yl)ethanol)

• Molecular Formula: C23H25FN2O

• Molecular Weight: 364.46 g/mol

• CAS Number: 132810-10-7

  
  

Pharmacological Action:

Blonanserin is an atypical antipsychotic medication primarily used for the treatment of schizophrenia. It exhibits its pharmacological effects through its action on various neurotransmitter receptors in the brain:

1.     Dopamine D2 Receptor Antagonism:

o    Blonanserin preferentially binds to and blocks the dopamine D2 receptors, thereby reducing dopaminergic activity, which is typically elevated in schizophrenic patients. This action helps in alleviating symptoms such as delusions and hallucinations.

2.     Serotonin 5-HT2A Receptor Antagonism:

o    Blonanserin also has antagonistic effects on serotonin 5-HT2A receptors. By blocking these receptors, blonanserin helps in balancing serotonin levels in the brain, contributing to mood stabilization and reducing negative symptoms like social withdrawal and apathy.

3.     Efficacy in Treating Acute and Chronic Symptoms:

o    Studies have shown that blonanserin is effective in managing both acute schizophrenic episodes and long-term maintenance therapy. It is known to improve overall functioning and quality of life for patients with schizophrenia.

4.     Favorable Side Effect Profile:

o    Compared to some other antipsychotics, blonanserin has a lower risk of causing weight gain, metabolic syndrome, and extrapyramidal side effects (movement disorders), making it a preferable option for many patients.