Chemical Name: 2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose sulfamate
English Name: Topiramate
Molecular Formula: C12H21NO8S
Molecular Weight: 339.36 g/mol
CAS Number: 97240-79-4
Pharmacological Actions
Pharmacological Class: Topiramate is classified as an anticonvulsant and antimigraine agent.
Mechanism of Action: 1. Voltage-Gated Sodium Channels: Topiramate inhibits the voltage-gated sodium channels, stabilizing the neurons and preventing the initiation and propagation of seizures. 2. Enhancement of GABA Activity: It enhances the activity of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, via the GABA-A receptor. This leads to increased inhibitory effects on neuron firing. 3. Inhibition of Glutamate Receptors: It inhibits the kainate/AMPA subtype of glutamate receptors, which decreases excitatory synaptic transmission. 4. Carbonic Anhydrase Inhibition: Topiramate has mild inhibitory effects on carbonic anhydrase isoenzymes, which may contribute to its antiepileptic effects.
