Alternative Names: 3-Hydroxytyramine; Catecholamine; 4-(2-Aminoethyl)-1,2-benzenediol Hydrochloride; Dopamine HCl, etc.
CAS Number: 62-31-7
EINECS Number: 200-527-8
Molecular Formula: C8H11NO2·HCl
Molecular Weight: 189.64
Physical Properties
Melting Point: 240-241°C (decomposes)
Density: 1.4 g/cm³
Boiling Point: 337.7 °C at 760 mmHg
Flash Point: 11°C
Solubility in Water: Readily soluble
Other Solubilities: Soluble in methanol and hot 95% ethanol, soluble in sodium hydroxide solution, insoluble in ether, chloroform, and benzene
Chemical Properties
Stability: Stable, but incompatible with strong oxidizing agents
Flammability: Flammable, decomposes to produce toxic oxides of nitrogen and chloride gas upon burning
Uses
Dopamine Hydrochloride is an essential biochemical reagent and a vasopressor medication.
Clinically, it is primarily used to treat various types of shock, especially those accompanied by decreased myocardial contractility and renal insufficiency.
Dopamine Hydrochloride stimulates cardiac β-receptors, increasing myocardial contractility and cardiac output. Simultaneously, it stimulates dopamine receptors and α-receptors, causing vasodilation in the kidney, mesenteric, coronary, and cerebral vessels, leading to increased blood flow and renal blood flow, which enhances glomerular filtration rate and promotes increased urine output and urinary sodium excretion.
Safety
Dopamine Hydrochloride is classified as an irritant and requires proper precautions during handling.
Its acute toxicity data indicates an LD50 of 2859 mg/kg in rats and 4361 mg/kg in mice.
Storage and Transportation
Dopamine Hydrochloride should be stored in a low-temperature, ventilated, and dry environment, away from direct sunlight and high temperatures.
During transportation, ensure that the packaging is intact to prevent leakage and moisture.