Chemical Name: 2-(4,5-Bis(4-methylphenyl)-2-imidazolyl)pyridine
Molecular Formula: C16H18N4
Molecular Weight: 266.34 g/mol
CAS Number: 3605-01-4
Pharmacological Actions of Piribedil
Dopamine D2/D3 Agonist: Piribedil is primarily utilized as a dopamine receptor agonist, specifically targeting D2 and D3 receptors in the central nervous system. This direct stimulation helps in compensating for the deficient dopaminergic neurotransmission seen in conditions such as Parkinson’s disease.
Antiparkinsonian Effects: By activating dopamine receptors, Piribedil enhances dopaminergic activity, leading to improvements in motor control, reduction in tremors, and overall mitigation of Parkinsonian symptoms.
Cognitive Enhancement: Apart from its motor benefits, Piribedil has been found to improve certain cognitive functions by modulating dopaminergic neurotransmission, which is crucial for cognitive processes.
Vasodilation and Increased Blood Flow: Piribedil has vasodilatory properties that aid in improving blood flow, particularly in cerebral and peripheral regions. This can be beneficial in conditions where increased blood flow is required.
Adrenergic Receptor Antagonism: Apart from dopamine receptor activity, Piribedil also has some antagonistic action on alpha-adrenergic receptors which can contribute to vasodilation and blood flow improvements.
