I. Basic Information

• English Name: Edaravone

• CAS Number: 89-25-8

• Molecular Formula: C10H10N2O

• Molecular Weight: 174.199 (may be rounded to 174.20 in different sources)

II. Physical and Chemical Properties

• Density: 1.2±0.1 g/cm³

• Melting Point: 126-131°C (may vary slightly, e.g., 126-128°C)

• Boiling Point: 333.0±11.0 °C at 760 mmHg

• Flash Point: 155.2±19.3 °C

• Vapor Pressure: 0.0±0.7 mmHg at 25°C

• Solubility: Soluble in hot water, alcohol, acids, and bases; slightly soluble in benzene; insoluble in ethers and petroleum ether

III. Pharmacological Action

Edaravone exerts multiple protective effects in the body primarily through the following mechanisms:

• Free Radical Scavenging: Edaravone scavenges free radicals in the body, reducing oxidative stress-induced damage.

• Inhibition of Apoptosis: By inhibiting the apoptotic process, it protects cells from damage.

• Blocking Non-enzymatic Peroxidation and Lipoxygenase Activity: Reducing cell damage caused by these enzymatic reactions.

IV. Clinical Applications

Edaravone is clinically used to improve neurological symptoms, activities of daily living, and functional impairments caused by acute cerebral infarction.