Solubility: Soluble in water (approximately 12 mg/mL)
Category and Uses
Product Category: Active Pharmaceutical Ingredient (API)
Uses: Esmolol Hydrochloride is an ultra-short-acting, selective β1-adrenoceptor blocker belonging to the aryloxypropanolamine class. It primarily inhibits β1 receptors by competing for catecholamine binding sites, leading to reduced resting and exercise heart rates, decreased blood pressure, and reduced myocardial oxygen consumption. Clinically, it is used for the treatment of supraventricular arrhythmias and acute myocardial ischemia. It also shows significant efficacy in treating acute myocardial infarction, unstable angina, postoperative hypertension, and other conditions.
Safety Information
Risk Codes: R52/53
Safety Statements: S61
Storage Conditions: Typically stored at lower temperatures (e.g., -20°C) to maintain stability
Preparation Method
Esmolol Hydrochloride can be prepared through multiple synthetic steps starting from p-hydroxybenzaldehyde, involving condensation, reduction, esterification, amination, and salt formation.
Precautions
When handling Esmolol Hydrochloride, follow relevant safety procedures, wear appropriate personal protective equipment, and be aware of potential adverse reactions such as hypotension, peripheral ischemia, confusion, and others.
