Chemical Name: 6-(4-Aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone
CAS Number: 141505-33-1
Molecular Formula: C14H12N6O
Molecular Weight: 280.29 (Note: Some sources may list it as 280.28 due to slight differences in calculation precision)
Physical and Chemical Properties
Melting Point: 216-219°C (dec.)
Density: 1.3±0.1 g/cm³ or 1.33 g/cm³ (depending on sources and purity)
Refractive Index: 1.673
Uses
Levosimendan is a positive inotropic agent primarily used in the treatment of acute heart failure. It works by increasing the sensitivity of myocardial contractile proteins to Ca2+ and opening ATP-sensitive K+ channels in cell membranes, thereby enhancing myocardial contractility while dilating peripheral and coronary blood vessels, reducing preload and afterload on the heart.
Levosimendan also exhibits anti-inflammatory, antioxidant, anti-apoptotic, and anti-stunning pharmacological effects, which can reduce mortality and improve prognosis in patients with heart failure.
Safety and Precautions
Levosimendan has relatively mild adverse effects, with serious adverse reactions being rare. Common adverse reactions include headache, tachycardia, etc.
Market and Supply
Levosimendan, as an important cardiovascular drug, has widespread applications in the market.
In summary, the chemical substance corresponding to CAS number 141505-33-1 is Levosimendan, a crucial cardiovascular drug with multiple pharmacological effects and broad application prospects.
