Basic Chemical Information

• Chemical Name: Letermovir

• Molecular Formula: C29H28F4N4O4

• Molecular Weight: 572.55 g/mol

• CAS Number: 917389-32-3

Pharmacological Action

Pharmacological Class: Antiviral agent, specifically used to prevent cytomegalovirus (CMV) infection.

Mechanism of Action:
- Cytomegalovirus Terminase Complex Inhibition: Letermovir works by inhibiting the CMV DNA terminase complex, which is crucial for viral DNA processing and packaging. This action prevents the replication of CMV by interfering with the cleavage and packaging of viral DNA into the capsid.
- Selective Activity: Letermovir is selective for CMV and does not demonstrate activity against other viruses, including other members of the Herpesviridae family.