Basic Information

• Product Name: Tigecycline

• CAS Number: 220620-09-7

• Molecular Formula: C29H39N5O8

• Molecular Weight: 585.65

• EINECS Number: 685-736-6

Physical and Chemical Properties

• Appearance: Yellow to orange powder

• Melting Point: 164-166°C

• Boiling Point: 890.9°C (predicted)

• Density: 1.455 g/cm³ (predicted)

• Solubility: Soluble in DMSO (at least 25 mg/ml)

• Storage Conditions: Store in a cool, dark place under an inert atmosphere, refrigerated below -20°C. Once dissolved in a solvent, use within one month if stored at -20°C.

Chemical Characteristics

• Tigecycline is a derivative of minocycline, with a glycylamido substitution at the C-9 position of the minocycline structure. This substitution pattern is not found in any natural or semisynthetic tetracycline drug.

• The presence of a glycylamido group enhances its antibacterial activity and reduces bacterial resistance.

Pharmacological Effects

• Tigecycline exerts its antibacterial action by binding to the bacterial 30S ribosomal subunit, preventing the entry of aminoacyl-tRNA molecules into the A-site of the ribosome, thereby inhibiting bacterial protein synthesis.

• Tigecycline has a broad spectrum of activity covering G+ cocci, G- bacilli, MRSA, ESBL-producing Enterobacteriaceae, Stenotrophomonas maltophilia, and multi-drug-resistant Acinetobacter baumannii.