Molecular Weight: Approximately 585.64 (note that there may be slight variations in molecular weight values from different sources, but they are generally close)
Chemical Properties
Solubility: Soluble in DMSO (Dimethyl Sulfoxide)
Storage Conditions: Typically recommended to store at -20°C for improved solubility. Can be heated to 37°C and agitated in an ultrasonic bath for a period of time.
Pharmacological Action
Class: Fosinopril Sodium is an angiotensin-converting enzyme (ACE) inhibitor belonging to the third generation of ACE inhibitors containing a phosphonic acid group.
Mechanism of Action: It inhibits ACE activity by binding to the zinc ion at the ACE active site, thereby reducing the production of angiotensin II, causing vasodilation and lowering blood pressure.
Pharmacological Characteristics: After oral administration, Fosinopril Sodium is hydrolyzed and converted to its active form, Fosinoprilat. Its absorption rate ranges from 18% to 41%. Antacids may affect the absorption of Fosinopril Sodium, reducing its bioavailability.
Clinical Applications
Indications: Fosinopril Sodium is suitable for patients with various types of hypertension, offering protective effects on the heart, brain, kidneys, and other organs.
Combination Therapy: When combined with diuretics, it can be used to treat heart failure.
Safety and Regulation
Safety Information: Fosinopril Sodium may cause skin irritation, serious eye irritation, and respiratory irritation. It is suspected to be harmful to fertility or to the unborn child. Therefore, when handling and using this substance, strictly follow safety procedures and wear appropriate personal protective equipment.
