I. Basic Information

• CAS Number: 68377-91-3

• English Name: Arotinolol Hydrochloride

• Chinese Name: 盐酸阿罗洛尔

• Molecular Formula: C15H22ClN3O2S3

• Molecular Weight: Approximately 408.002 (may vary slightly depending on the source)

II. Physical and Chemical Properties

• Density: 1.35 g/cm³

• Boiling Point: 599.8ºC at 760 mmHg

• Melting Point: 234-235.5°C (dec)

• Flash Point: 316.6ºC

• Storage Conditions: Store in a cool, dry, well-ventilated area, separate from food and feedstuffs.

III. Uses

Arotinolol Hydrochloride is a non-selective α/β-adrenergic receptor blocker with multiple pharmacological effects:

1. Antihypertensive: It exerts its antihypertensive effect through β-receptor blockade without increasing peripheral vascular resistance, complemented by its α-receptor blocking action.

2. Anti-anginal: It inhibits excessive cardiac function and reduces myocardial oxygen consumption through β-receptor blockade, correcting the imbalance between myocardial oxygen supply and demand.

3. Antiarrhythmic: Demonstrates antiarrhythmic effects in animal models.

4. Antitremor: With β2-receptor blocking action on skeletal muscles, it exhibits antitremor effects.

Additionally, Arotinolol Hydrochloride has been studied for its potential use in obesity-related diseases and for improving aortic stiffness in rats.

IV. Conclusion

Arotinolol Hydrochloride is a pharmaceutical compound with multiple pharmacological effects, primarily used in the treatment of hypertension, angina, and other conditions.