Aminocaproic Acid (CAS No. 1319-82-0)

Aminocaproic Acid, identified by its Chemical Abstracts Service (CAS) number 1319-82-0, is a crucial medicinal compound with a wide array of applications in the medical and pharmaceutical fields.

Basic Information

• CAS Number: 1319-82-0

• Chemical Name: Aminocaproic Acid

• Common Names: 6-Aminocaproic Acid, ε-Aminocaproic Acid

• Chemical Formula: C6H13NO2

• Molecular Weight: Calculated based on the chemical formula (not directly stated in the reference)

• Appearance: White crystalline powder

• Purity: Typically 98% to 99% or higher, depending on the manufacturer and intended use

Physical Properties

• Density: 1.042 (may vary under different conditions)

• Melting Point: 205-207°C

• Boiling Point: 255.6°C at 760 mmHg

• Refractive Index: 1.465

• Polar Surface Area (PSA): 63.32000

• LogP (Octanol-Water Partition Coefficient): 1.29040

• Solubility: Soluble in water, slightly soluble in ethanol, practically insoluble in chloroform or ether

Pharmacological Effects

Aminocaproic Acid is a specific antifibrinolytic agent that functions primarily by:

1. Inhibiting the Activation of Plasminogen: Preventing the conversion of plasminogen into plasmin, thereby blocking the fibrinolytic process.

2. Direct Inhibition of Plasmin: At high concentrations, it can also directly inhibit plasmin activity, enhancing its hemostatic effects.

Clinical Applications

Due to its pharmacological properties, Aminocaproic Acid is used in various clinical settings, including:

1. Surgical Hemostasis: Reducing postoperative bleeding and promoting wound healing in cardiovascular, orthopedic, and transplant surgeries.

2. Obstetric and Gynecological Bleeding: Managing postpartum hemorrhage, miscarriage bleeding, and other obstetrical and gynecological bleeding situations.

3. Other Bleeding Conditions: Treating pulmonary hemorrhage, upper gastrointestinal bleeding, and other bleeding disorders.