Indobufen, also known as Indobufenum, is a platelet aggregation inhibitor primarily used in the treatment of cardiovascular diseases. Below is a detailed introduction to Indobufen:
Basic Information
English Name: Indobufen
Alternative Names: Indobufenum, Ibostrin, K-3920
Molecular Formula: C18H17NO3
Molecular Weight: 295.3325
CAS Number: 63610-08-2
Drug Class: Cardiovascular Agent / Antithrombotic
Type of Medication: Platelet Aggregation Inhibitor
Pharmacological Action
Indobufen exerts its effects by inhibiting platelet aggregation through suppression of the release reactions induced by certain platelet activators (such as ADP, 5-HT, platelet factor 4, β-thromboglobulin, etc.) and influencing arachidonic acid metabolism. It does not affect plasma parameters related to blood coagulation but can moderately prolong bleeding time, which returns to normal upon discontinuation. Additionally, Indobufen acts as a reversible inhibitor of platelet cyclooxygenase (Cox) activity, inhibiting the synthesis of thromboxane A2 (TxA2) and reducing tissue factor in monocytes.
Indications
Indobufen is primarily used for the treatment and prevention of the following conditions:
Atherosclerotic ischemic cardiovascular diseases
Ischemic cerebrovascular diseases
Peripheral arterial diseases
Dyslipidemia
Venous thrombosis
Vascular complications associated with diabetes
Prevention of thrombosis during hemodialysis
Adverse Reactions
Adverse reactions to Indobufen include:
Gastrointestinal reactions: nausea, vomiting, dyspepsia, abdominal pain, constipation, etc.
Neurological reactions: headache, dizziness, etc.
Skin allergic reactions: urticarial-like skin reactions, etc.
Bleeding reactions: gingival bleeding, epistaxis, etc. Rare cases may present with gastric ulcer, gastrointestinal bleeding, and hematuria.
Drug Interactions
When co-administered with chloral hydrate and non-steroidal anti-inflammatory drugs (NSAIDs) like phenylbutazone, the free plasma concentration of Indobufen may increase.
Concurrent use with vasodilators may enhance therapeutic effects.
In summary, Indobufen is an essential platelet aggregation inhibitor that plays a crucial role in the treatment of cardiovascular diseases. However, it is essential to consider its indications, dosage and administration, precautions, potential adverse reactions, and drug interactions when using this medication.
