Chemical Name: Cefradine (also known as Cephradine, Velosef, Ceporex, etc.)
Chemical Formula: C16H19N3O4S
Molecular Weight: 349.405 g/mol
CAS Number: 38821-53-3
EINECS Number: 254-137-8
Cefradine is an organic compound belonging to the first-generation, semi-synthetic cephalosporins with broad-spectrum antibacterial activity.
Physical and Chemical Properties
Melting Point: 140-142°C
Boiling Point: 693.1±55.0°C at 760 mmHg
Density: Approximately 1.5±0.1 g/cm³
Flash Point: 373.0±31.5°C
Solubility: Easily soluble in water and also soluble in DMSO (note that DMSO's hygroscopicity may affect the solubility of the product)
Pharmacological Effects
Cefradine exhibits activity against both Gram-positive and Gram-negative pathogens, effectively eradicating most microorganisms that are known to be resistant to penicillin G, penicillin V, and ampicillin due to the production of penicillinase.
Cefradine has been studied for use in urinary-genital, gastrointestinal, and respiratory tract infections, as well as skin and soft tissue infections.
Cefradine inhibits sunlight-induced skin inflammation by directly inhibiting TOPK (T-LAK cell-originated protein kinase).
Clinical Applications
Cefradine is indicated for the treatment of acute pharyngitis, tonsillitis, otitis media, bronchitis, pneumonia, and other respiratory infections, as well as urinary-genital infections and skin and soft tissue infections caused by susceptible bacteria.
Cefradine is an oral formulation and is not suitable for the treatment of severe infections.
