PM2061P-4-Aminopyridine
4-Aminopyridine
The English name of the compound | 4-Aminopyridine | Compound Chinese | 4-氨基吡啶 |
CASNo. | 504-24-5 | Molecular | C5H6N2 |
Molecular weight | 94.11450 | Precise quality | 94.05310 |
LogP | 1.24500 | PSA | 38.91000 |
Appearance and character | White to pale yellow crystals | Melting point | 157 °C |
Stability | Stable under normal temperatures and pressures. | Storage conditions | The warehouse is ventilated and low-temperature dry, and stored separately with oxidants, acids and food additives |
Densit | 1.26 | Flash point | 156 °F |
Boiling point | 273°C(lit.) |
SAFETY DATA SHEETS
According to the UN GHS revision 8
Version: 1.0
Creation Date: July 15, 2019
Revision Date: July 15, 2019
1. Identification
1.1 GHS Product identifier
Product name | 4-pyridylamine |
1.2 Other means of identification
Product number | - |
Other names | Dalfampridine; pyridin-4-amine; EL 970 |
1.3 Recommended use of the chemical and restrictions on use
Identified uses | Industrial and scientific research uses. |
Uses advised against | no data available |
1.4 Supplier's details
Company | Free copy from XiXisys.com. For reference only. |
Address | Free copy from XiXisys.com. For reference only. |
Telephone | Free copy from XiXisys.com. For reference only. |
Fax | Free copy from XiXisys.com. For reference only. |
1.5 Emergency phone number
Emergency phone number | Free copy from XiXisys.com. For reference only. |
Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
2. Hazard identification
2.1 Classification of the substance or mixture
Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity – single exposure, Category 3
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
2.2 GHS label elements, including precautionary statements
Pictogram(s) |
| |
Signal word | Danger | |
Hazard statement(s) | H300 Fatal if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation H411 Toxic to aquatic life with long lasting effects | |
Precautionary statement(s) | ||
Prevention | P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. | |
Response | P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P313 If skin irritation occurs: Get medical advice/attention. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P312 Call a POISON CENTER/doctor/…if you feel unwell. P391 Collect spillage. | |
Storage | P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. | |
Disposal | P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. | |
2.3 Other hazards which do not result in classification
no data available
3. Composition/information on ingredients
3.1 Substances
Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
4-pyridylamine | 4-pyridylamine | 504-24-5 | 207-987-9 | 100% |
4. First-aid measures
4.1 Description of necessary first-aid measures
General advice
Medical attention is required. Consult a doctor. Show this safety data sheet (SDS) to the doctor in attendance.
If inhaled
Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.
Following skin contact
Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.
Following eye contact
Rinse with pure water for at least 15 minutes. Consult a doctor.
Following ingestion
Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.
4.2 Most important symptoms/effects, acute and delayed
Material may be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes. Material affects neural transmission. In sufficient concentrations, material may cause metabolic acidosis, respiratory arrest, and cardiac arrhythmias. (EPA, 1998)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Pancuronium is a pharmacologic antidote and is recommended in severely poisoned human patients. Propranolol appears to block some of the cardiac toxicity (such as cardiac arrhythmias) of 4-aminopyridine. Seizures can be treated with diazepam. In severe cases, phenobarbital or phenytoin can be given, if no response to diazepam. In case of avitrol ingestion, general symptomatic and supportive treatment includes emesis, gastric lavage, activated charcoal, and cathartic sodium thiosulfate. Bicarbonate should be added tot he fluids to treat acidosis.
5. Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special protective equipment for firefighters: Wear self contained breathing apparatus for fire fighting if necessary.
5.2 Specific hazards arising from the chemical
Material may produce irritating or poisonous gases in fire. Runoff from fire control water may give off irritating or poisonous gases. (EPA, 1998)
5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.
6.2 Environmental precautions
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.
6.3 Methods and materials for containment and cleaning up
Personal precautions: Wear respiratory protection. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
7. Handling and storage
7.1 Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2 Conditions for safe storage, including any incompatibilities
Keep container tightly closed in a dry and well-ventilated place.
8. Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
no data available
8.2 Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).
Skin protection
Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.
Thermal hazards
no data available
9. Physical and chemical properties
Physical state | Pyridine, 4-amino- is a white crystalline material with no odor. Used as an avicide, an intermediate and as a fixer for some textile dyes. (EPA, 1998) It has been approved by the FDA for use as a treatment for multiple sclerosis. |
Colour | White crystals |
Odour | Odorless |
Melting point/ freezing point | 210°C(lit.) |
Boiling point or initial boiling point and boiling range | 273°C(lit.) |
Flammability | no data available |
Lower and upper explosion limit / flammability limit | no data available |
Flash point | 9°C(lit.) |
Auto-ignition temperature | no data available |
Decomposition temperature | no data available |
pH | no data available |
Kinematic viscosity | no data available |
Solubility | no data available |
Partition coefficient n-octanol/water | log Kow = 0.32 |
Vapour pressure | 2.09X10-4 mm Hg at 20 deg C |
Density and/or relative density | no data available |
Relative vapour density | no data available |
Particle characteristics | no data available |
10. Stability and reactivity
10.1 Reactivity
No rapid reaction with air. No rapid reaction with water.
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
PYRIDINE, 4-AMINO- neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Strong oxidizing agents, Strong acids, Acid chlorides, Acid anhydrides
10.6 Hazardous decomposition products
When heated to decomposition it emits toxic fumes of /nitrogen oxides/.
11. Toxicological information
Acute toxicity
· Oral: LD50 Dog oral 3.7 mg/kg
· Inhalation: no data available
· Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Cancer Classification: Group D Not Classifiable as to Human Carcinogenicity
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
12. Ecological information
12.1 Toxicity
· Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill); Conditions: freshwater, static; Concentration: 2820 ug/L for 96 hr (95% confidence interval: 2300-3500 ug/L)
· Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea) juvenile; Conditions: freshwater, static, 21 deg C, hardness 40 mg/L CaCO3; Concentration: 17000 ug/L for 24 hr; Effect: intoxication, immobilization /formulation
· Toxicity to algae: no data available
· Toxicity to microorganisms: no data available
12.2 Persistence and degradability
AEROBIC: 4-Aminopyridine, present at 100 mg/L, reached 0% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). In a screening test, which utilized 5 mL garden soil suspensions with glucose, yeast extract and mineral salts, 4-aminopyridine completely degraded in greater than 170 days under both aerobic and anaerobic conditions(2). For flooded soils, 76.4 and 79.0% of the original radio labeled 4-aminopyridine was mineralized to CO2 within 60 days in a Fargo clay and Barnes sandy loam soil at 20 deg C and pHs of 7.7, and 7.4, respectively(3). In addition, only 6, 18 and 24% of the original radio labeled 4-aminopyridine was mineralized to CO2 within 60 days in a Barnes sandy loam, Towner loamy fine sand and Fargo clay at 20 deg C and pHs of 7.4, 7.2 and 7.7, respectively(3). An aerobic biological screening study, which utilized a 10 mg/L yeast extract and an Aeric Ochraqualf soil for inocula, indicated that 4-aminopyridine is not readily biodegradable(4); at 28 deg C and a pH of 7, less than 1% of an initial 14.6 ppm of 4-aminopyridine was mineralized in greater than 30 days as evidenced via the release of inorganic nitrogen(4). An acclimated aerobic soil grab sample study demonstrated slow biodegradation of 4-aminopyridine(5). 4-Aminopyridine was added to Fincastle silt loam (Aeric Ochraqualf) with a pH of 6.7 and incubated at 25 deg C(5); within 64 days, 6.1% of the available nitrogen was released to inorganic forms(5); sterilized controls lost 14.9% of the starting material to volatilization, but did not release inorganic nitrogen(5). Aerobic biotic half-lives of 4-aminopyridine in soil are reported to range between 3 and 32 months(6).
12.3 Bioaccumulative potential
BCF values of <0.2-0.6 (at 50 mg/L) and <1.8-7.2 (at 5 mg/L concentration) were measured in carp (Cyprinus carpio) which were exposed over an 8-week period for 4-aminopyridine(1). According to a classification scheme(2), these BCF ranges suggest the potential for bioconcentration in aquatic organisms is low.
12.4 Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc for 4-aminopyridine can be estimated to be 35(SRC). According to a classification scheme(2), this estimated Koc value suggests that 4-aminopyridine is expected to have very high mobility in soil. The pKa of 4-aminopyridine is 9.17(3), indicating that this compound will exist predominantly in cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). In addition, aromatic amines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(5,6), suggesting that mobility may be much lower in some soils(SRC).
12.5 Other adverse effects
no data available
13. Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14. Transport information
14.1 UN Number
ADR/RID: UN2671 (For reference only, please check.) | IMDG: UN2671 (For reference only, please check.) | IATA: UN2671 (For reference only, please check.) |
14.2 UN Proper Shipping Name
ADR/RID: AMINOPYRIDINES (o-, m-, p,) (For reference only, please check.) | IMDG: AMINOPYRIDINES (o-, m-, p,) (For reference only, please check.) | IATA: AMINOPYRIDINES (o-, m-, p,) (For reference only, please check.) |
14.3 Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.) | IMDG: 6.1 (For reference only, please check.) | IATA: 6.1 (For reference only, please check.) |
14.4 Packing group, if applicable
ADR/RID: II (For reference only, please check.) | IMDG: II (For reference only, please check.) | IATA: II (For reference only, please check.) |
14.5 Environmental hazards
ADR/RID: No | IMDG: No | IATA: No |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available
15. Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
Chemical name | Common names and synonyms | CAS number | EC number |
4-pyridylamine | 4-pyridylamine | 504-24-5 | 207-987-9 |
European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
EC Inventory | Listed. | ||
United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
China Catalog of Hazardous chemicals 2015 | Listed. | ||
New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
Vietnam National Chemical Inventory | Listed. | ||
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
Korea Existing Chemicals List (KECL) | Listed. | ||
16. Other information
Information on revision
Creation Date | July 15, 2019 |
Revision Date | July 15, 2019 |
Abbreviations and acronyms
· CAS: Chemical Abstracts Service
· ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
· RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
· IMDG: International Maritime Dangerous Goods
· IATA: International Air Transportation Association
· TWA: Time Weighted Average
· STEL: Short term exposure limit
· LC50: Lethal Concentration 50%
· LD50: Lethal Dose 50%
· EC50: Effective Concentration 50%
References
· IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
· HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
· IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
· eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
· CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
· ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
· ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
· Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
· ECHA - European Chemicals Agency, website: https://echa.europa.eu/
